Wednesday, May 4, 2011

How Haematology Analysers Are Used in Biotechnology Applications

In clinical haematology, haematopoieses is the normal part of the analytical procedure. The breaking down and separation of the components of whole human blood can be achieved using a variety of methods, and the newer haematology analysers used today are advancing in technology to make manual counting of blood components unnecessary.

A haematology analyser uses many methods for counting human blood components, red blood cells, white blood cells, thrombocytes or platelets, and other species of cells that are common in human blood. Red blood cells have morphologies that can indicate disease or other health issues, so having an instrument for detecting these subtle changes is paramount for the diagnostician. Certain anemias can be detected with today's haematology analysers.


Anemias are dysfunction in the red blood cells production. This can be evident in the size, shape, and hemoglobin content of each red blood cell (RBC). RBC's are analysed for these parameters within a hematology analyser by sorting them through a tiny aperture, which allows only one cell at a time to flow. An electronic charge field surrounds the aperture, and as the cell flows through the opening, the charge is disrupted, causing microvolt changes, which can be calculated by computer software.

How Haematology Analysers Are Used in Biotechnology Applications

Different sized cells cause a unique charge in the aperture. Shapes can also be determined in this manner, such as poikilocytosis, or the major dissimilar shaping of RBC's. Anisocytosis, or different sized cells, are detected at the same time as the unique shaped cells. This has developed into a highly advanced and technically efficient process. Diagnoses of many blood diseases can be ascertained in a matter of minutes using the hematology analyser.

White blood cells, or WBC's, are the protectors of our bodies within the blood. They combat disease and infection, and without them, we would not survive. Many diseases can be diagnosed using a haematology analyser by examining the types of WBC's present in the whole blood samples of humans. A normal white blood cell count in a male human should be from three to 10 per thousand cells, and any deviation from this is cause for alarm. Haematology analysers can count, accurately, the WBC's present in a known volume of aspirated human blood.

Morphology of the WBC's is also an important parameter in which these analysers can provide. Normal differential peripheral blood smears were usually done manually in the past, but now can be accurately ascertained using the haematology instrument. The sizes of the nucleus of cells are detected using a particle-sizing instrument that can accurately determine the size and shape of the cells being tested.

Red blood cells are also examined in this way because certain shapes of the cells can indicate diseases or defects in the blood system. Having an accurate and efficient analyser is so vital that they are found in every clinical and medical laboratory around the world. Veterinarians also use these systems for animal blood testing, as animal also procure diseases and have disorders which can wreak havoc with their health. Without the indubitable analyser in the clinical laboratory setting, many samples would be slow to results, and accuracy may be compromised.

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Take a look at other relevant information about haematology analysis including chemistry analyzer content and applications as well as haematology analyser product profiles.

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